Chromokinesin

WebBackground: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets … WebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the …

Chromokinesin KIF4A teams up with stathmin 1 to regulate ... - PubMed

WebSep 21, 2011 · Interestingly, from its positioning on the chromosome arms, Hklp2 seems to restrict spindle pole separation. In the present review, we summarize the current knowledge of the function and regulation of the different kinesins associated with chromosome arms during cell division, including Hklp2 as a novel member of this so-called chromokinesin ... WebMar 3, 2003 · The human chromokinesin Kid is a plus end-directed microtubule-based motor Junichiro Yajima Department of Life Sciences, Graduate School of Arts and … opengl change color https://shipmsc.com

Chromokinesins: multitalented players in mitosis - PubMed

WebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … WebJul 16, 1996 · The Kinesin-4 (formerly Chromokinesin/KIF4) family tree was obtained using the heuristic search method of PAUP v4.0b10 (Swofford, 2002), a maximum parsimony program, and random stepwise addition. The tree is one of two optimal trees that resulted from 600 trees that were built. The bootstrap values adjacent to the nodes are the … WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain … iowa state football fox

Chromokinesin: Kinesin superfamily regulating cell …

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Chromokinesin

Pathogenic mutations in the chromokinesin KIF22 disrupt

WebJul 24, 2024 · Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated modification of KIF4A by the ubiquitin-like protein SUMO. We mapped lysine … WebNational Center for Biotechnology Information

Chromokinesin

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WebJun 27, 2024 · Chromokinesin, Fe-S cluster, Genome stability INTRODUCTION Recent studies have attempted to expand the list of genes contributing to chromosome instability (CIN) in yeast. These studies resulted in the identification of many yeast CIN genes that can be organized into a number of functional groups. WebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the …

WebJul 1, 2005 · Download : Download full-size image Figure 1. Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic … WebMay 1, 2016 · Chromokinesin contains both a kinesin motor-like domain and an unusual basic-leucine zipper DNA-binding domain. Its mRNA is readily detectable in proliferating cells, but not in postmitotic cells.

WebJul 24, 2024 · (A) Chromokinesin KIF4A is required for the positioning of mitotic chromosomes and stabilization of the bipolar spindle. In cytokinesis, KIF4A localizes at … WebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the kinesin-4/Kif4 and kinesin-10/Kif22 …

WebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome …

WebSep 21, 2005 · The human chromokinesin Kid/Kinesin-10 is a plus end-directed MT-based motor ( Shiroguchi et al ., 2003; Yajima et al ., 2003) that binds both MTs and chromosomes ( Tokai et al ., 1996 ). Kid has been reported to play an important role in chromosomal movement along MTs during prometaphase and metaphase. iowa state football fieldWebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the meiotic spindle, which is self-organized in ... iowa state football game today on tvWebMar 6, 2015 · The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154 , 1135–1146 (2001) . opengl characterWebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the … iowa state football game live online freeiowa state football game timesWebAug 14, 2010 · Chromokinesin KIF4 appears as reduced expression in human gastric carcinoma and associates with differentiation of gastric carcinoma. Chromokinesin KIF4 is previously reported to play an intriguing role in tumorigenesis [].To investigate the critical role of chromokinesin KIF4 in human gastric cancer, we examined 23 gastric carcinoma … opengl c exampleWebGao J, Sai N, Wang C, et al. Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo. Tumour Biol. 2011;32(1):53–61. 20. Wu G, Zhou L, Khidr L, et al. A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. 2008;7(13):2013–2024. 21. opengl chart library