WebBackground: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets … WebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the …
Chromokinesin KIF4A teams up with stathmin 1 to regulate ... - PubMed
WebSep 21, 2011 · Interestingly, from its positioning on the chromosome arms, Hklp2 seems to restrict spindle pole separation. In the present review, we summarize the current knowledge of the function and regulation of the different kinesins associated with chromosome arms during cell division, including Hklp2 as a novel member of this so-called chromokinesin ... WebMar 3, 2003 · The human chromokinesin Kid is a plus end-directed microtubule-based motor Junichiro Yajima Department of Life Sciences, Graduate School of Arts and … opengl change color
Chromokinesins: multitalented players in mitosis - PubMed
WebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … WebJul 16, 1996 · The Kinesin-4 (formerly Chromokinesin/KIF4) family tree was obtained using the heuristic search method of PAUP v4.0b10 (Swofford, 2002), a maximum parsimony program, and random stepwise addition. The tree is one of two optimal trees that resulted from 600 trees that were built. The bootstrap values adjacent to the nodes are the … WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain … iowa state football fox