Flcn autophagy

Author: tmdt

August undefined, 2024

Tīmeklis2024. gada 10. febr. · Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Tīmeklis2013. gada 4. dec. · Suppression of autophagy further enhances paclitaxel-induced apoptosis in FLCN-deficient renal cancer cells. Our results suggest that paclitaxel …

AMPK-dependent phosphorylation is required for transcriptional

Tīmeklis2024. gada 18. marts · FLCN is the gene associated with the Birt-Hogg-Dubé neoplastic syndrome in humans, characterized by predisposition to renal cell carcinoma, skin … Tīmeklis2014. gada 22. jūl. · Folliculin (FLCN), the protein product of the FLCN gene, is a poorly characterized tumor suppressor protein, currently linked to multiple cellular … contact conversion wizard fritzbox

Autophagy-related compound screening for the development of …

Tīmeklis2024. gada 21. nov. · FLCN-FNIP1 is recruited to damaged mitochondria, and this process is inhibited in cells expressing RAB7AS72A. Moreover, nonphosphorylatable … TīmeklisThe present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder canc Tīmeklis2013. gada 4. dec. · Our results indicated that autophagy induced by paclitaxel in FLCN-null renal cancer cells plays a protective role, and the inhibition of autophagy could increase apoptosis induced by paclitaxel treatment in these cancer cells. Materials and methods Reagents and antibodies contact congressman scott fitzgerald

AMPK-dependent phosphorylation is required for transcriptional

FLCN protein expression summary - The Human Protein Atlas

Tīmeklis2024. gada 19. febr. · FLCN is a tumor suppressor gene which controls energy homeostasis through regulation of a variety of metabolic pathways including … Tīmeklis2024. gada 14. apr. · Autophagy is a highly conserved process that functions to transport cargos to the lysosome for recycling and cellular degradation in eukaryotes … edwin moses morehouse collegeTīmeklis2014. gada 24. apr. · Autophagy increases energy levels upon loss of flcn-1. Autophagy is a process that generates catabolic substrates for mitochondrial ATP production and allows cellular macromolecules to be recycled. Since we did not observe a difference in oxidative damage between wild-type and flcn-1 ... edwin moser my life

"Tīmeklis2024. gada 5. marts · FLCN folliculin [ (human)] Gene ID: 201163, updated on 8-Dec-2024. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. " - Flcn autophagy

Flcn autophagy

Tīmeklis2014. gada 13. nov. · In addition, ULK1 (unc-51-like autophagy activating kinase 1), a homolog of yeast ATG1, is believed to be another downstream effector of mTORC1. ... Concurrently, amino acids promote the GEF activity of Ragulator for GDP-bound RagA/B and the GAP activity of FLCN-FNIP1/2 and LRS for GTP-bound RagC/D, … Tīmeklis2024. gada 21. marts · FLCN (Folliculin) is a Protein Coding gene. Diseases associated with FLCN include Pneumothorax, Primary Spontaneous and Birt-Hogg …

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TīmeklisLegend. Settings. Analysis Tīmeklis2024. gada 15. janv. · Abstract. Germline mutations in the novel tumor suppressor gene FLCN are responsible for the autosomal dominant inherited disorder Birt …

Tīmeklis2015. gada 16. marts · Germline alteration of the folliculin ( FLCN) gene, a novel tumor suppressor, is responsible for Birt–Hogg–Dubé (BHD) syndrome, an inherited kidney … Tīmeklis2014. gada 22. jūl. · Folliculin (FLCN), the protein product of the FLCN gene, is a poorly characterized tumor suppressor protein, currently linked to multiple cellular …

The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. Folliculin (FLCN) is also associated with Birt–Hogg–Dubé syndrome, which is an … Skatīt vairāk Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 … Skatīt vairāk Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin … Skatīt vairāk • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports … Skatīt vairāk • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. … Skatīt vairāk TīmeklisThe FLCN gene provides instructions for making a protein called folliculin. Researchers have not determined the protein's function, but they believe it may act as a tumor …

Tīmeklis2024. gada 10. nov. · In FLCN-depleted TSC2 KO cells, co-transfection of FNIP2 with stably-expressed WT FLCN or activated FLCN F118D (lanes 8–9 or 12–13 of Fig. 7d, lanes 9–13 of Fig. S9a) led to a rescue of p ...

Tīmeklis2024. gada 12. aug. · Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to... contact conwy county borough councilTīmeklisDuring acute starvation, autophagy is rapidly engaged by AMPK (AMP-activated protein kinase) activation and MTOR (mechanistic target of rapamycin kinase) complex 1 … contact cooled air compressorTīmeklisMutations in FLCN lead to the dysregulation of TFE3, as indicated by the constitutively nuclear localization of TFE3 in a BHD cancer cell line . ... Of the 83 autophagy genes we tested, less than 10% showed more than a twofold increase upon overexpression of TFE3. However, the up-regulated genes encode proteins that function as key … edwin motteTīmeklis2024. gada 14. sept. · The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–activating protein (GAP) that regulates mTORC1 phosphorylation of MiT-TFE transcription factors, controlling lysosome biogenesis and … edwin moses heightTīmeklis2024. gada 11. sept. · Autophagy is primarily regulated by the transcription factors TFEB and TFE3, which are negatively regulated by mTORC1. Given that FLCN is an … edwin moses origisTīmeklis2024. gada 28. okt. · The folliculin (FLCN) protein has been recently identified as a central regulatory node governing whole body energy homeostasis, and we … contact coolerTīmeklisFLcN is a positive driver of autophagy. (A) hK2 control and FLCN knockdown cells were transfected with the ptfMaP1Lc3B vector, fixed, and examined by confocal microscopy. Representative maximal Z-projection images of cells showing the RFP-GFP-MaP1Lc3B puncta are shown in the FLCN FLCN edwin moses training